Childhood adversity needs more research, not less

| 05 Mar 2015 | 02:58

To the Editor:
Each year, one in five U.S. children suffers from a mental disorder. These illnesses range from depression to anxiety to alcohol abuse. Astoundingly, almost 5 percent of children are addicted to drugs.

Science may never be able to eliminate mental illness. But scientists are learning how to help those who suffer from it — especially children. Research in animals, for example, is yielding insights into how stress experienced early in life can result in behavioral and emotional problems in adulthood.

Unfortunately, that research is under attack. Some activists claim that it's needlessly cruel. It's not. What is cruel, however, is shutting down a line of scientific inquiry that may help scientists mitigate — or even reverse — the effects of childhood psychological adversity.

Significant levels of psychological stress are surprisingly common among children. There are more than a half million new cases of child abuse each year, according to the Department of Health and Human Services.

Such psychiatric stress can result in debilitating mental disorders. Children who suffer abuse and mistreatment early in life, for instance, are prone to substance abuse, domestic violence, and suicidal thoughts.

These negative outcomes pose substantial costs for society — including higher rates of crime, drug addiction, homelessness, domestic abuse, and incarceration. This much we know.

But we don't know why adversity in childhood often results in these harms later in life — or how we can stop them.

Scientists are beginning to answer those questions, thanks in large part to research with primates.

One such line of research involves isolating young animals, such as rats and monkeys, from their mothers in a scientific setting. By introducing this stressor to an animal early in life, researchers can study the effects of difficult childhood experiences on future health and behavior.

For instance, a 2009 study published in Frontiers in Neurobiology suggested that early-life stress disrupted the "HPA axis" — a central hormonal loop in the body — and could lead to aggression and mood disorders in humans.

That discovery points the way to a treatment. There are already several drugs in existence — developed with the help of animal models — that can address this sort of hormonal malfunction. Other studies on animals suggest that therapies or approaches for treating the effects of early-life stress must be flexible and adjustable to the individual.

Critics of this type of childhood development research claim that animal models are no longer necessary, thanks to new technologies like fMRI machines that allow for detailed human brain scans.

But technology simply cannot replicate the results that animal research can deliver — results that inform a number of scientific disciplines, from neurobiology to behavioral psychology to sociology.

That's exactly what the scientists at the American Psychological Association told several Members of Congress in a recent letter defending childhood development research at the National Institutes of Health.

Further, animal research is transparent. Under federal regulations, a committee of scientists and private citizens must review and approve studies involving animals at each research facility.

Primate research — like the studies at the NIH — could relieve the extraordinary human suffering that early-life stress and childhood trauma all too often yield. The potential payback from this research would spread to people at all levels of society.

Given the stakes, we can't afford to forswear established scientific research that could help children everywhere. Researchers must be allowed to face these challenges head-on.

Paul McKellips
Foundation for Biomedical Research

Washington, D.C.